Tennessee Genealogical Society
Basic Terms in DNA Testing
Looking into DNA testing can be confusing at times. Here are some DNA terms
that will help you out.
DNA
DNA stands for Deoxyribonucleic acid. DNA is the substance inside each and every
cell in your body that tells that cell how to divide. When you were first formed
from your mom's egg and your dad's sperm, you got one half of your DNA from each
one. The two combined to make your own unique DNA, in a single cell. That one
DNA split, and you had two cells. They kept splitting, and soon you were born.
Since you got one half of your DNA from your mom and one half from your dad, DNA
testing can see how you compare to those people ... and you can work your way
back through the family tree.
Chromosome
Chromosomes are what make up DNA. Human beings have 23 chromosomes in their DNA.
These are long, paired threads. In each chromosome pair, you have one thread
from your mom and one from your dad. The 23rd chromosome is what makes you male
or female. If you have two X chromosomes in that pair, you're female. If you
have one and and one Y, you are male. Since your mom has two Xs, she had to give
you an X. Your dad had an X and Y in his DNA, so he is who randomly determined
(depending which sperm got to you first) whether you were a boy or a girl.
Y-Chromosome Testing
Because only males have the Y chromosome, and only a father can give one to his
son, this is perfect for DNA testing purposes. If you have two lines that are
father-son related, and supposedly have a common male ancestor, you can use
Y-DNA testing to see if this is true or not.
Markers
A human gene is MASSIVE and cannot be compared letter to letter. It would take
years to do that. Instead, researchers have come up with certain key spots, or
"markers". They choose the markers that are easiest to work with, and
compare just those marker locations. If all of the markers match, they know the
genes have a very high probability of matching.
Mitochondria
Mitochondria are the powerhouses of the cell. In fact, George Lucas was so
intrigued with them that they inspired his "miticlorians" in his Star
Wars movies. Mitochondria are passed only from a mother to her children. So
while a son can get the mitochondria, he cannot pass them down to HIS children.
Therefore, mtDNA testing is perfect for tracing up female family lines.
Buccal
Most genealogy tests nowadays do not involve any blood! It is COMPLETELY
painless. You are given a plastic "spoon". You scrape that gently
along the inside of your cheek. This is called a buccal test. The gentle
scraping takes off a few skin cells, just like rubbing your hands together
releases a tiny cloud of dead skin cells. You send the spoon back into the
testing company, and VOILA you are done.
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